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Impact of solidification on micromeritic properties and dissolution rate of self-nanoemulsifying delivery system loaded with docosahexaenoic acid.

Published on Mar 23, 2020in Drug Development and Industrial Pharmacy2.367
· DOI :10.1080/03639045.2020.1742143
Dipanjoy Ghosh1
Estimated H-index: 1
(LPU: Lovely Professional University),
Sachin Kumar Singh10
Estimated H-index: 10
(LPU: Lovely Professional University)
+ 19 AuthorsAnkit Awasthi1
Estimated H-index: 1
(LPU: Lovely Professional University)
Abstract
AbstractDevelopment of self-nanoemulsifying drug delivery systems (SNEDDS) of docosahexaenoic acid (DHA) is reported with the aim to achieve enhanced dissolution rate. The optimized composition of ...
  • References (29)
  • Citations (0)
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References29
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#1Rajan Kumar (LPU: Lovely Professional University)H-Index: 1
#2Rubiya Khursheed (LPU: Lovely Professional University)H-Index: 2
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Abstract Fisetin is a plant derived flavonoid that possesses anti-cancer, anti-oxidant and anti-Parkinson's activities. However, due to its lipophilicity it suffers from dissolution rate limited oral bioavailability that reduces its therapeutic efficacy. In order to overcome this issue self-nanoemulsifying drug delivery system (SNEDDS) of fisetin were formulated and characterized for droplet size, shape, zeta potential, cell viability, dissolution and permeability studies. Prepared SNEDDS (1.2 m...
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#1Harmanpreet Singh (G.N.D.U.: Guru Nanak Dev University)H-Index: 3
#2Sandip Nathani (IITR: Indian Institute of Technology Roorkee)H-Index: 1
Last. Subheet Kumar Jain (G.N.D.U.: Guru Nanak Dev University)H-Index: 6
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Abstract Docosahexanoic acid (DHA) is an essential element for proper development of brain and treatment of cognitive disorders. Oily nature, poor water dispersibility, intestinal permeability, organoleptic characteristic of microalgae oil (DHA oil) limits oral delivery and therapeutic performance. An effort has been made to prepare a novel water soluble Solid Self Nano-Emulsifying Drug Delivery System (S-SNEDDS) of DHA oil having improved physical & oxidative stability, bioavailability and ther...
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#1Afzal Hussain (BIT Mesra: Birla Institute of Technology, Mesra)H-Index: 6
#2Faiyaz Shakeel (KSU: King Saud University)H-Index: 3
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Abstract The present investigation was performed to develop a rifampicin (RIF)-loaded solidified self-nanoemulsifying drug delivery system (SNEDDS) (solidified RIF-OF1) for in vitro and in vivo evaluations. Optimized formulations were tested for their powder flow characteristics, loading efficiency, and in vitro dissolution (at pH-1.2, 6.8 and 7.4). Compatibility studies were also performed. The formulations were also tested for hemocompatibility, intestinal permeation, histopathological effects...
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#1GargVarun (LPU: Lovely Professional University)H-Index: 1
#2KaurPuneet (WSU: Washington State University)H-Index: 1
Last. WadhwaSheetu (LPU: Lovely Professional University)H-Index: 1
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Abstract An attempt has been made to prepare solid self-nanoemulsifying drug delivery system (SNEDDS) of polypeptide-k (PPK) and curcumin (CRM) using Labrafil M1944 CS as oil, Tween-80 as surfactan...
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Abstract The present research work explored the prospective of self-nanoemulsifying drug delivery system (SNEDDS) to improve the oral bioavailability of NBT and its anti-inflammatory effect. Nabumetone (NBT) is a poorly aqueous soluble drug that demonstrates low bioavailability after oral administration. NBT-SNEDDS was prepared by using Capryol-90, Tween-80 and polyethylene glycol-400 (PEG-400) via pseudo-ternary phase diagram. Different components of SNEDDS were curtained and found an optimal r...
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#1Mohsin Kazi (KSU: King Saud University)H-Index: 4
#2Mohammed Al-Swairi (KSU: King Saud University)H-Index: 1
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Objective: The aim of this study was to investigate the in vitro and in vivo performance of self-nanoemulsifying drug delivery systems (SNEDDS) of talinolol (TAL), a poorly water soluble drug. Method: SNEDDS of TAL were prepared using various oils, non-ionic surfactants and/or water-soluble co-solvents and assessed visually/by droplet size measurement. Equilibrium solubility of TAL in the anhydrous and diluted SNEDDS was conducted to achieve the maximum drug loading. The in vitro dissolution exp...
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#1Eman Abd-Elhakeem (Cairo University)H-Index: 1
#2Mahmoud H. Teaima (Cairo University)H-Index: 3
Last. Galal M. El Mahrouk (Cairo University)H-Index: 2
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Abstract The purpose of this study is to develop solid self-nanoemulsifying drug delivery systems (S-SNEDDS) for oral bioavailability enhancement of Clopidogrel (CLP). CLP is an anti-platelet drug used to prevent heart strokes. It suffers from low bioavailability due to extensive hepatic metabolism. Two pseudo-ternary phase diagrams were constructed using different oils, bioenhancing surfactants and co-surfactants. SNEDDS were evaluated for their globule size, polydispersity index and in-vitro d...
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#1Parth Sharma (LPU: Lovely Professional University)H-Index: 1
#2Sachin Kumar Singh (LPU: Lovely Professional University)H-Index: 10
Last. Rubiya Khursheed (LPU: Lovely Professional University)H-Index: 2
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Abstract In the present study, different solid self-nanoemulsifying drug delivery system (S-SNEDDS) was formulated by using porous hydrophilic and hydrophobic carriers to improve the dissolution rate and bioavailability of simvastatin (SIM). The prepared liquid-SNEDDS composed of Labrafil M 1944 CS/ Tween-80/ Ethanol (20% / 53.33%/26.67% v/v) with 0.1% SIM, resulted droplet size of 40.69 nm. The hydrophobic carriers used were Aerosil-200, Syloid 244FP, Syloid XDP 3150, Magnesium stearate, Micro ...
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#1Yandi Syukri (UII: Islamic University of Indonesia)H-Index: 2
#2Ronny Martien (UGM: Gadjah Mada University)H-Index: 7
Last. Agung Endro Nugroho (UGM: Gadjah Mada University)H-Index: 17
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Abstract This study aimed to conduct a preparation and characterization of andrographolide isolated from Andrographis paniculata Nees (AND)-loaded Self-Nano Emulsifying Drug Delivery System (SNEDDS) to improve its oral dissolution and bioavailability. The selection of oil, surfactant and co-surfactant components for preliminary screening of self-nano emulsifying formulation was determined by solubility study of AND in various vehicles. Ternary phase diagrams were constructed to identify the nano...
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#1Sarvi Yadav Rajesh (LPU: Lovely Professional University)H-Index: 1
#2Sachin Kumar Singh (LPU: Lovely Professional University)H-Index: 10
Last. Saurabh Singh (LPU: Lovely Professional University)H-Index: 4
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AbstractDevelopment of self-nanoemulsifying drug delivery systems (SNEDDS) of glimepiride is reported with the aim to achieve its oral delivery. Lauroglycol FCC, Tween-80, and ethanol were used as oil, surfactant, and co-surfactant, respectively as independent variables. The optimized composition of SNEDDS formulation (F1) was 10% v/v Lauroglycol FCC, 45% v/v Tween 80, 45% v/v ethanol, and 0.005% w/v glimepiride. Further, the optimized liquid SNEDDS were solidified through spray drying using var...
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