The C291R Tau Variant Forms Different Types of Protofibrils
Abstract
Mutations in the MAPT gene can lead to disease-associated variants of tau. However, the pathological mechanisms behind these genetic tauopathies are poorly understood. Here, we characterized the aggregation stages and conformational changes of tau C291R, a recently described MAPT mutation with potential pathogenic functions. The C291R variant of the tau four-repeat domain (tau-K18; a functional fragment with increased aggregation propensity...
Paper Details
Title
The C291R Tau Variant Forms Different Types of Protofibrils
Published Date
Mar 18, 2020
Volume
13
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