Furan Carboxylic Acids Production with High Productivity by Cofactor‐engineered Whole‐cell Biocatalysts

Furan carboxylic acids are useful chemicals in various industries. In this work, biocatalytic production of furan carboxylic acids was reported with high productivities by cofactor‐engineered Escherichia coli cells. NADH oxidase (NOX) was introduced into E. coli harboring aldehyde dehydrogenases (ALDHs) to promote intracellular NAD + regeneration, thus significantly enhancing ALDH‐catalyzed oxidation. These engineered biocatalysts were capable...