Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors.

Volume: 117, Issue: 14, Pages: 8094 - 8103
Published: Apr 7, 2020
Abstract
Coronaviruses (CoVs) are positive-sense RNA viruses that can emerge from endemic reservoirs and infect zoonotically, causing significant morbidity and mortality. CoVs encode an endoribonuclease designated EndoU that facilitates evasion of host pattern recognition receptor MDA5, but the target of EndoU activity was not known. Here, we report that EndoU cleaves the 5'-polyuridines from negative-sense viral RNA, termed PUN RNA, which is the product...
Paper Details
Title
Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors.
Published Date
Apr 7, 2020
Volume
117
Issue
14
Pages
8094 - 8103
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