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Multilayered Particles Based on Biopolyelectrolytes as Potential Peptide Delivery Systems

Published on Jan 1, 2020in Polymer Science Series A0.984
· DOI :10.1134/S0965545X20010125
Natalia Zashikhina3
Estimated H-index: 3
,
D. V. Yudin1
Estimated H-index: 1
+ 2 AuthorsEvgenia Korzhikova-Vlakh4
Estimated H-index: 4
Abstract
A series of amphiphilic charged copolymers of amino acids is synthesized, and their binding to cationic and anionic peptides is studied. The resulting interpolyelectrolyte complexes are additionally stabilized by cationic/anionic polysaccharides using surface layering. The positive effect of coatings on the release rate of peptides and decrease in the cytotoxicity and increase in the stability of the resulting peptide delivery systems in biological media is shown.
  • References (34)
  • Citations (1)
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References34
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#1Cameron L. Nemeth (University of California, Berkeley)H-Index: 6
#2William R. Lykins (University of California, Berkeley)H-Index: 2
Last. Tejal A. Desai (University of California, Berkeley)H-Index: 63
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Purpose To develop a planar, asymmetric, micro-scale oral drug delivery vehicle by i) fabricating microdevice bodies with enteric materials, ii) efficiently and stably loading sensitive drug molecules, and iii) capping microdevices for controlled drug release.
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#1Ma Rie KimH-Index: 1
#2Teng FengH-Index: 1
Last. Ying ChauH-Index: 17
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Combination therapy is a promising form of treatment. In particular, co-treatment of P3 and QBP1 has been shown to enhance therapeutic effect in vivo in treating polyglutamine diseases. These peptide drugs, however, face challenges in clinical administration due to poor stability, inability to reach intracellular targets, and lack of method to co-deliver both drugs. Here we demonstrate two methods of co-encapsulating the peptide drugs via polymer poly(ethylene glycol)-block-polycaprolactone (PEG...
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#1Brandon Bumbaca (UB: University at Buffalo)H-Index: 1
#2Zhe Li (UB: University at Buffalo)H-Index: 3
Last. Dhaval K. Shah (UB: University at Buffalo)H-Index: 15
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Abstract Protein and peptide conjugates have become an important component of therapeutic and diagnostic medicine. These conjugates are primarily designed to improve pharmacokinetics (PK) of those therapeutic or imaging agents, which do not possess optimal disposition characteristics. In this review we have summarized preclinical and clinical PK of diverse protein and peptide conjugates, and have showcased how different conjugation approaches are used to obtain the desired PK. We have classified...
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#1Zhixing LiuH-Index: 1
#2Fuyi ZhouH-Index: 10
Last. Yong QianH-Index: 8
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Abstract We had reported an electrochemical assay for dopamine with high sensitivity and selectivity based on dual molecular recognition strategy and amplification of DNA–Au bio–bar codes. In this assay, carbon nanotubes were first immobilized on the glass carbon electrode surface. Subsequently, a boronic acid-functionalized pyrene probe was self-assembled on the sidewalls of carbon nanotubes via π–π stacking interactions as a capture probe. 3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide es...
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Abstract In this research poly( l -lysine)- b -poly( l -leucine) (PLys- b -PLeu) polymersomes were developed. It was shown that the size of nanoparticles depended on pH of self-assembly process and varied from 180 to 650 nm. The biodegradation of PLys- b -PLeu nanoparticles was evaluated using in vitro polypeptide hydrolysis in two model enzymatic systems, as well as in human blood plasma. The experiments on the visualization of cellular uptake of rhodamine 6 g-loaded and fluorescein-labeled nan...
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There is increasing evidence supporting a link between cognitive dysfunctions and impaired brain insulin signalling. Insulin therapy has previously been tested as an approach to ameliorate brain insulin resistance and deficiency in patients with various brain disorders. However, current strategies for insulin delivery to the brain may induce severe hypoglycaemia when injected peripherally or show poor uptake when delivered intranasally. Recently, we have shown that intracranial transplantation o...
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#1Gauravkumar Agrawal (BAMU: Dr. Babasaheb Ambedkar Marathwada University)
#2Pravin S. Wakte (BAMU: Dr. Babasaheb Ambedkar Marathwada University)H-Index: 11
Last. Santosh ShelkeH-Index: 2
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The objective of the present investigation was to formulate and characterize the human insulin entrapped Eudragit S100 microspheres containing protease inhibitors and to develop an optimized formulation with desirable features. A w/o/w multiple emulsion solvent evaporation technique was employed to produce microspheres of human insulin using Eudragit S-100 as coating material and polyvinyl alcohol as a stabilizer. The resultant microspheres were evaluated for drug-excipient compatibility, encaps...
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#1Violeta Chavez (University of Texas at Austin)H-Index: 5
#2Richard S.P. Huang (Hoffmann-La Roche)H-Index: 1
Last. Audrey Wanger (University of Texas at Austin)H-Index: 28
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Polymyxins are vital antibiotics for the treatment of multiresistant Gram-negative ESKAPE pathogen infections. However, their clinical value is limited by their high nephrotoxicity and neurotoxicity, as well as their poor permeability and absorption in the gastrointestinal tract. This review focuses on various polymyxin delivery systems that improve polymyxin bioavailability and reduce drug toxicity through targeted and controlled release. Currently, the most suitable systems for improving oral,...
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