Radiation resistance in head and neck squamous cell carcinoma: dire need for an appropriate sensitizer

Volume: 39, Issue: 18, Pages: 3638 - 3649
Published: Mar 10, 2020
Abstract
Radiation is a significant treatment for patients with head and neck cancer. Despite advances to improve treatment, many tumors acquire radiation resistance resulting in poor survival. Radiation kills cancer cells by inducing DNA double-strand breaks. Therefore, radiation resistance is enhanced by efficient repair of damaged DNA. Head and neck cancers overexpress EGFR and have a high frequency of p53 mutations, both of which enhance DNA repair....
Paper Details
Title
Radiation resistance in head and neck squamous cell carcinoma: dire need for an appropriate sensitizer
Published Date
Mar 10, 2020
Journal
Volume
39
Issue
18
Pages
3638 - 3649
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