Reconstructing the blood metabolome and genotype using long-range chromatin interactions

—Maintenance of tight controls on circulating blood metabolites is crucial to normal, healthy tissue and organismal function. A number of single nucleotide polymorphisms (SNPs) have been associated with changes in the levels of blood metabolites. However, the impacts of the metabolite-associated SNPs are largely unknown because they fall within non-coding regions of the genome. —We aimed to identify genes and tissues that are linked to changes...