Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome

Volume: 11, Issue: 1, Pages: 1363 - 1363
Published: Mar 13, 2020
Abstract
Nucleosome organization has been suggested to affect local mutation rates in the genome. However, the lack of de novo mutation and high-resolution nucleosome data has limited the investigation of this hypothesis. Additionally, analyses using indirect mutation rate measurements have yielded contradictory and potentially confounding results. Here, we combine data on >300,000 human de novo mutations with high-resolution nucleosome maps and find...
Paper Details
Title
Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome
Published Date
Mar 13, 2020
Volume
11
Issue
1
Pages
1363 - 1363
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