Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome
Abstract
Nucleosome organization has been suggested to affect local mutation rates in the genome. However, the lack of de novo mutation and high-resolution nucleosome data has limited the investigation of this hypothesis. Additionally, analyses using indirect mutation rate measurements have yielded contradictory and potentially confounding results. Here, we combine data on >300,000 human de novo mutations with high-resolution nucleosome maps and find...
Paper Details
Title
Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome
Published Date
Mar 13, 2020
Journal
Volume
11
Issue
1
Pages
1363 - 1363
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