Targeting the cyclin-dependent kinase 5 in metastatic melanoma

Volume: 117, Issue: 14, Pages: 8001 - 8012
Published: Mar 19, 2020
Abstract
Significance Melanomas are notorious due to their propensity to form lethal metastases. Currently, no treatments are available to stop the metastatic spread. We observed that in malignant melanomas, a protein called the cyclin-dependent kinase 5 (CDK5) is essential for melanoma metastasis. Using mouse and human melanoma cells, we demonstrated that in this tumor type CDK5 promotes the metastatic spread by directly phosphorylating a...
Paper Details
Title
Targeting the cyclin-dependent kinase 5 in metastatic melanoma
Published Date
Mar 19, 2020
Volume
117
Issue
14
Pages
8001 - 8012
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