Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro
Abstract
Inhibition of acid sphingomyelinase (ASM), a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine, may serve as an investigational tool or a therapeutic intervention to control many diseases. Specific ASM inhibitors are currently not sufficiently characterized. Here, we found that 1-aminodecylidene bis-phosphonic acid (ARC39) specifically and efficiently (>90%) inhibits both lysosomal and secretory...
Paper Details
Title
Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro
Published Date
Jun 1, 2020
Journal
Volume
61
Issue
6
Pages
896 - 910
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