Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity
Abstract
Tumour cell phagocytosis by antigen presenting cells (APCs) is critical to the generation of antitumour immunity. However, cancer cells can evade phagocytosis by upregulating anti-phagocytosis molecule CD47. Here, we show that CD47 blockade alone is inefficient in stimulating glioma cell phagocytosis. However, combining CD47 blockade with temozolomide results in a significant pro-phagocytosis effect due to the latter's ability to induce...
Paper Details
Title
Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity
Published Date
Mar 20, 2020
Journal
Volume
11
Issue
1
Pages
1508
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