Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects

Volume: 31, Issue: 6, Pages: 1120 - 1135.e7
Published: Jun 1, 2020
Abstract
Anti-obesity drugs in the amphetamine (AMPH) class act in the brain to reduce appetite and increase locomotion. They are also characterized by adverse cardiovascular effects with origin that, despite absence of any in vivo evidence, is attributed to a direct sympathomimetic action in the heart. Here, we show that the cardiac side effects of AMPH originate from the brain and can be circumvented by PEGylation (PEGyAMPH) to exclude its central...
Paper Details
Title
Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects
Published Date
Jun 1, 2020
Volume
31
Issue
6
Pages
1120 - 1135.e7
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