Visceral adipose tissue Tregs and the cells that nurture them

Visceral adipose tissue (VAT) is a primary site for storage of excess energy, but it also serves as an important endocrine organ that impacts organismal metabolism. Chronic, low‐grade inflammation of VAT, and eventually systemically, is one of the major drivers of obesity‐associated insulin resistance and metabolic abnormalities. A unique population of regulatory T cells (Tregs), with a distinct transcriptional profile and antigen receptor...