Myeloid-specific deficiency of pregnane X receptor decreases atherosclerosis in LDL receptor-deficient mice

Volume: 61, Issue: 5, Pages: 696 - 706
Published: May 1, 2020
Abstract
The pregnane X receptor (PXR) is a nuclear receptor that can be activated by numerous drugs and xenobiotic chemicals. PXR thereby functions as a xenobiotic sensor to coordinately regulate host responses to xenobiotics by transcriptionally regulating many genes involved in xenobiotic metabolism. We have previously reported that PXR has pro-atherogenic effects in animal models, but how PXR contributes to atherosclerosis development in different...
Paper Details
Title
Myeloid-specific deficiency of pregnane X receptor decreases atherosclerosis in LDL receptor-deficient mice
Published Date
May 1, 2020
Volume
61
Issue
5
Pages
696 - 706
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