Betaine attenuates LPS-induced downregulation of Occludin and Claudin-1 and restores intestinal barrier function
Abstract
The intestinal epithelial barrier, which works as the first line of defense between the luminal environment and the host, once destroyed, it will cause serious inflammation or other intestinal diseases. Tight junctions (TJs) play a vital role to maintain the integrity of the epithelial barrier. Lipopolysaccharide (LPS), one of the most important inflammatory factors will downregulate specific TJ proteins including Occludin and Claudin-1 and...
Paper Details
Title
Betaine attenuates LPS-induced downregulation of Occludin and Claudin-1 and restores intestinal barrier function
Published Date
Mar 4, 2020
Journal
Volume
16
Issue
1
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