Low FVC/TLC in Preserved Ratio Impaired Spirometry (PRISm) is associated with features of and progression to obstructive lung disease

One quarter of individuals with Preserved Ratio Impaired Spirometry (PRISm) will develop airflow obstruction, but there are no established methods to identify these individuals. We examined the utility of FVC/TLC in identifying features of obstructive lung disease. The ratio of post-bronchodilator FVC and TLC CT from chest CT (FVC/TLC CT ) among current and former smokers with PRISm (FEV 1 /FVC ≥ 0.7 and FEV1 < 80%) in COPDGene was used to...