Clostridioides difficile infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease

Volume: 117, Issue: 14, Pages: 8064 - 8073
Published: Mar 20, 2020
Abstract
Significance Clostridioides difficile is the most common cause of hospital-acquired diarrhea. It is responsible for more than half of all hospital enteric infections and >90% of mortalities resulting from these infections. Gut damage sustained during C. difficile infection is devastating, inducing epithelial damage deep into the gut tissue, to regions where stem cells responsible for tissue repair reside. Our work has shown that...
Paper Details
Title
Clostridioides difficile infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease
Published Date
Mar 20, 2020
Volume
117
Issue
14
Pages
8064 - 8073
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