Generalizing convolution neural networks on stain color heterogeneous data for computational pathology

Hematoxylin and Eosin (H&E) are one of the main tissue stains used in histopathology to discriminate between nuclei and extracellular material while performing a visual analysis of the tissue. However, histopathology slides are often characterized by stain color heterogeneity, due to different tissue preparation settings at different pathology institutes. Stain color heterogeneity poses challenges for machine learning-based computational...