Match!

Effect of Intestinal Levodopa-Carbidopa Infusion on Pharyngeal Dysphagia: Results from a Retrospective Pilot Study in Patients with Parkinson's Disease.

Published on Mar 11, 2020in Parkinson's Disease
· DOI :10.1155/2020/4260501
Bendix Labeit1
Estimated H-index: 1
(WWU: University of Münster),
Inga Claus3
Estimated H-index: 3
+ 3 AuthorsTobias Warnecke24
Estimated H-index: 24
Abstract
Background. Pharyngeal dysphagia is a common symptom of Parkinson’s disease (PD) leading to severe complications. PD-related pharyngeal dysphagia (PDrPD) may significantly improve in up to half of patients following acute oral levodopa challenge. Objective. The aim of this study was to investigate the effects of levodopa-carbidopa intestinal gel (LCIG) on PDrPD. Methods. Forty-five PD patients under LCIG treatment were available for retrospective analysis. In all patients with PDrPD who underwent flexible endoscopic evaluation of swallowing (FEES) in the clinical “on-state” both before and after implementation of LCIG treatment, FEES videos were systematically reassessed. PDrPD was characterized using a PD-specific FEES score evaluating premature bolus spillage, penetration/aspiration, and pharyngeal residue. Further, the duration of white-out was assessed, as a parameter for pharyngeal bradykinesia. Results. Eleven patients with PDrPD (mean age 74.6 ± 4.4 years; mean Hoehn and Yahr stage 3.8 ± 0.6) received FEES both before and after the onset of LCIG treatment. The mean swallowing score improved from 14.9 ± 7.3 to 13.0 ± 6.9 after implementation of LCIG; however, this difference was not significant ( ). Premature bolus spillage decreased significantly ( ) from 5.4 ± 1.1 to 3.6 ± 1.0, and white-out duration decreased significantly ( ) from 984 ± 228 ms to 699 ± 131 ms after implementation of LCIG. Conclusions. LCIG may affect PDrPD and reduce premature bolus spillage and pharyngeal bradykinesia. Future studies with larger sample sizes are required to follow-up on these pilot results and identify which factors predict a good response of PDrPD to LCIG treatment.
  • References (39)
  • Citations (0)
📖 Papers frequently viewed together
24 Citations
1 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References39
Newest
#1Rainer DziewasH-Index: 1
Last. Tobias WarneckeH-Index: 24
view all 46 authors...
At present, the flexible endoscopic evaluation of swallowing (FEES) is one of the most commonly used methods for the objective assessment of swallowing. This multicenter trial prospectively collected data on the safety of FEES and also assessed the impact of this procedure on clinical dysphagia management. Patients were recruited in 23 hospitals in Germany and Switzerland from September 2014 to May 2017. Patient characteristics, professional affiliation of the FEES examiners (physicians or speec...
1 CitationsSource
#1Bendix LabeitH-Index: 1
#2Paul MuhleH-Index: 7
Last. Rainer DziewasH-Index: 34
view all 9 authors...
Source
#1Thomas Wichmann (Yerkes National Primate Research Center)H-Index: 43
Source
#2Thomas MarianH-Index: 4
Last. Tobias WarneckeH-Index: 24
view all 11 authors...
Source
#1Francesco Mozzanica (University of Milan)H-Index: 11
#2Rosaria Lorusso (University of Milan)H-Index: 2
Last. Antonio Schindler (University of Milan)H-Index: 21
view all 8 authors...
One of the major limitations of the fiberoptic endoscopic evaluation of swallowing (FEES) is related to the challenging application of temporal measures. Among them, Whiteout (WO) is due to pharyngeal and tongue base contraction and might be used as an estimation of the pharyngeal phase duration. The aims of this study were to evaluate the inter- and intrarater reliability of WO duration and to appraise the effects of age, sex, volume, and texture of the boluses on this temporal measurement. A t...
3 CitationsSource
#1Christina Pflug (UHH: University of Hamburg)H-Index: 3
#2Moritz Bihler (UHH: University of Hamburg)H-Index: 2
Last. Carsten Buhmann (UHH: University of Hamburg)H-Index: 23
view all 11 authors...
To assess the prevalence of dysphagia and its typical findings in unselected “real-world” Parkinson patients using an objective gold-standard method. This was a prospective, controlled, cross-sectional study conducted in 119 consecutive Parkinson patients of all stages independent of subjective dysphagia. Patients and 32 controls were clinically and endoscopically examined by flexible endoscopic evaluation of swallowing (FEES) to evaluate the deglutition with regard to three consistencies (water...
19 CitationsSource
#1Yoko Wakasugi (Tokyo Medical and Dental University)H-Index: 5
#2Toshiyuki YamamotoH-Index: 1
Last. Shunsuke Minakuchi (Tokyo Medical and Dental University)H-Index: 19
view all 6 authors...
Background and Objective We investigated the swallowing function in patients with Parkinson's disease (PD) using deteriorated tongue control because PD patients frequently exhibit an impaired oral stage of swallowing and the tongue movement affects to oral and pharyngeal stage. Methods In total, 201 PD patients (106 men, 95 women; mean age 70.6 ± 8.0 years; median Hoehn-Yahr Stage III) were studied. The patients swallowed 10 mL of liquid barium under videofluorography and their oral transit time...
5 CitationsSource
#1Ahmed A. OthmanH-Index: 19
Last. Sandeep DuttaH-Index: 18
view all 5 authors...
4 CitationsSource
#1Julie A. Y. Cichero (UQ: University of Queensland)H-Index: 22
#2Peter Lam (UBC: University of British Columbia)H-Index: 4
Last. Soenke StanschusH-Index: 2
view all 13 authors...
Dysphagia is estimated to affect ~8% of the world’s population (~590 million people). Texture-modified foods and thickened drinks are commonly used to reduce the risks of choking and aspiration. The International Dysphagia Diet Standardisation Initiative (IDDSI) was founded with the goal of developing globally standardized terminology and definitions for texture-modified foods and liquids applicable to individuals with dysphagia of all ages, in all care settings, and all cultures. A multi-profes...
77 CitationsSource
#1M. KarakocH-Index: 2
#2Mehmet Ilker YonH-Index: 2
Last. Fikri AkH-Index: 7
view all 7 authors...
We aimed to investigate the association between drooling and possible etiological factors in Parkinson’s disease (PD) and to determine its effect on the quality of life. Demographic data of the 63 patients with idiopathic PD were recorded. Radboud Oral Motor Inventory for Parkinson’s disease (ROMP) test was administered to all patients to evaluate speech, swallowing functions, and saliva control. The freezing of gait questionnaire (FOGQ) was used to evaluate gait and freezing of gait. Dynamic Pa...
5 CitationsSource
Cited By0
Newest