Abstract P272: Associations of an Epigenetic Biomarker of Aging and Healthspan With BMI Status and Metabolic Health in Adult African Americans: The Atherosclerosis Risk in Communities (ARIC) Study

Introduction: Individuals with obesity are thought to be protected against some chronic disease as long as they do not incur metabolic health (MH) conditions. A new epigenetic biomarker of accelerated biological aging and health span, PhenoAge, was developed using DNA methylation (DNAm) markers. We hypothesized that obesity would be associated with higher PhenoAge than normal weight and overweight individuals only in the presence of MH...