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Semi-solid extrusion 3D printing ODFs: an individual drug delivery system for small scale pharmacy.

Published on Mar 12, 2020in Drug Development and Industrial Pharmacy2.367
· DOI :10.1080/03639045.2020.1734018
Ting-Ting Yan (Guangdong Pharmaceutical University), Zhufen Lv3
Estimated H-index: 3
(Guangdong Pharmaceutical University)
+ 4 AuthorsYanzhong Chen3
Estimated H-index: 3
(Guangdong Pharmaceutical University)
Abstract
AbstractOrodispersible films (ODFs) are promising drug delivery systems for customized medicines as it provide an alternative approach to increase consumer acceptance by advantages of rapid dissolu...
  • References (37)
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#1Mengsuo Cui (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Yining Yang (SPU: Shenyang Pharmaceutical University)
Last. Pingtian Ding (SPU: Shenyang Pharmaceutical University)H-Index: 1
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Abstract Semi-solid extrusion (SSE) 3D printing is an innovative and promising method that is suitable for the fabrication of personalized dosage forms of tablets. The aim of this study is to develop and evaluate the effectiveness of SSE 3D printed tablets with novel internal structures. Twelve types of 3D printed tablets with pre-designed structures were developed. Glipizide was selected as the model drug and three different concentrations of the HPMC K100LV polymer were used in the 3D printing...
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#1Pinak Khatri (RU: Rutgers University)H-Index: 3
#2Mansi K. Shah (UTMB: University of Texas Medical Branch)H-Index: 5
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Abstract 3D printing: a layer-by-layer process to produce drug products has gained a lot of attention in recent years especially after its first FDA approval due to several advantages offered as an effort for an improved pharmacotherapy. This technology is indeed an old and widely used in other industries; however due to various regulations and complex application, it is yet to flourish in the pharmaceutical industry. Despite this fact, numerous dosage forms have been prepared and reported in th...
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#1Zhenjie Mo (Guangdong Pharmaceutical University)H-Index: 1
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#1Wen Chin Foo (NUS: National University of Singapore)H-Index: 1
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#1Magnus Edinger (UCPH: University of Copenhagen)H-Index: 6
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Abstract The use of inkjet printing (IJP) technology enables the flexible manufacturing of personalized medicine with the doses tailored for each patient. In this study we demonstrate, for the first time, the applicability of IJP in the production of edible dosage forms in the pattern of a quick response (QR) code. This printed pattern contains the drug itself and encoded information relevant to the patient and/or healthcare professionals. IJP of the active pharmaceutical ingredient (API)-contai...
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#1Yasmin Thabet (HHU: University of Düsseldorf)H-Index: 4
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Orodispersible films have been described as new beneficial dosage forms for special patient populations. Due to various production settings, different requirements on film formulations are required for non- continuous and continuous manufacturing. In this study, a continuous coating machine was qualified in regards of the process conditions for film compositions and their effects on the formed films. To investigate differences between both manufacturing processes, various film formulations of hy...
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#1G. Verstraete (UGent: Ghent University)H-Index: 7
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It was the aim of this study to develop high drug loaded (>30%, w/w), thermoplastic polyurethane (TPU)-based dosage forms via fused deposition modelling (FDM). Model drugs with different particle size and aqueous solubility were pre-processed in combination with diverse TPU grades via hot melt extrusion (HME) into filaments with a diameter of 1.75 ± 0.05 mm. Subsequently, TPU-based filaments which featured acceptable quality attributes (i.e. consistent filament diameter, smooth surface morpholog...
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Conventional immediate release dosage forms involve compressing the powder with a disintegrating agent that enables rapid disintegration and dissolution upon oral ingestion. Among 3D printing technologies, the fused deposition modelling (FDM) 3D printing technique has considerable potential for patient-specific dosage form. However, the use of FDM 3D printing in tablet manufacturing requires large portion of polymer, which slows down drug release through erosion and diffusion mechanisms. In this...
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#1Jenny Holländer (Åbo Akademi University)H-Index: 5
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Abstract The goal of this work was to study the printability of PDMS with a semi-solid extrusion printer in combination with the UV-assisted crosslinking technology using UV-LED light to manufacture drug containing structures. Structures with different pore sizes and different drug loadings were prepared containing prednisolone as a model drug. The work showed that it was possible to print drug-free and drug-loaded drug delivery devices of PDMS with the 3D printing technique used in this study. ...
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#1Witold Jamróz (Jagiellonian University Medical College)H-Index: 4
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Abstract Three dimensional printing technology is gaining in importance because of its increasing availability and wide applications. One of the three dimensional printing techniques is Fused Deposition Modelling (FDM) which works on the basis of hot melt extrusion–well known in the pharmaceutical technology. Combination of fused deposition modelling with preparation of the orodispersible film with poorly water soluble substance such as aripiprazole seems to be extra advantageous in terms of dis...
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