Abstract MP31: Blood DNA Methylation Signatures of Incident Coronary Heart Disease: An Epigenome-wide Analysis in the Strong Heart Study

Background: In the US, American Indians suffer a disproportionate burden of CHD compared to other racial/ethnic groups. Additional strategies are needed to identify individuals at risk. Objectives: Investigate the association of blood DNA methylation (DNAm) with incident CHD in the Strong Heart Study and the prediction ability of DNAm beyond traditional risk factors. We maximized prediction ability using Bayesian Hierarchical Cox (BHCox) and...