Supplementation with Seabuckthorn Oil Augmented in 16:1n–7tIncreases SerumTrans-Palmitoleic Acid in Metabolically Healthy Adults: A Randomized Crossover Dose-Escalation Study

In animal models cis-palmitoleic acid (9-hexadecenoic acid; 16:1n–7 c), a lipokine, improves insulin sensitivity, inflammation, and lipoprotein profiles; in humanstrans-palmitoleic acid (16:1n–7 t) has been associated with lower incidence of type 2 diabetes. The response to dose-escalation of supplements containing cis- and trans-palmitoleic acid has not been evaluated. We examined dose-escalation effects of oral supplementation with...