Toward prevention of bipolar disorder in at-risk children: Potential strategies ahead of the data

Despite the well-documented negative impact of untreated bipolar illness, approaches to early intervention in childhood-onset bipolar and related disorders are not well delineated. We reviewed the extant treatment literature on children at high risk for bipolar disorder, with definitions based on family history, childhood adversity, and prodromal symptoms. A panoply of approaches have been described, but most interventions are based on an...