Abstract MP59: Serum Sphingolipids and Incident Diabetes in US Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Introduction: Genetic or pharmacological inhibition of sphingolipid synthases prevented diabetes in animal studies. Scanty of cohort studies that examined circulating sphingolipids and incident diabetes yielded disparate findings. Hypothesis: Specific sphingolipids are associated with elevated risk of diabetes beyond traditional risk factors. Methods: Untargeted metabolomics profiling was performed using fasting serum samples collected from 2010...