Nasal high-flow versus non-invasive ventilation in patients with chronic hypercapnic COPD

Background: Despite the encouraging results of non-invasive ventilation (NIV) in chronic hypercapnic COPD patients, it is also evident that some patients do not tolerate NIV or do not benefit from it. We conducted a study in which COPD patients with stable, chronic hypercapnia were treated with NIV and NHF to compare effectiveness. Methods: In a multi-centered, randomized, controlled, cross-over design, patients received six weeks...