Multiplexed Mass Spectrometry of Individual Ions Improves Measurement of Proteoforms and Their Complexes

Volume: 17, Issue: 4, Pages: 391 - 394
Published: Mar 2, 2020
Abstract
An Orbitrap-based ion analysis procedure determines the direct charge for numerous individual protein ions to generate true mass spectra. This individual ion mass spectrometry (I2MS) method for charge detection enables the characterization of highly complicated mixtures of proteoforms and their complexes in both denatured and native modes of operation, revealing information not obtainable by typical measurements of ensembles of...
Paper Details
Title
Multiplexed Mass Spectrometry of Individual Ions Improves Measurement of Proteoforms and Their Complexes
Published Date
Mar 2, 2020
Volume
17
Issue
4
Pages
391 - 394
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