Platelet mitochondrial DNA methylation predicts future cardiovascular outcome in adults with overweight and obesity

The association between obesity and cardiovascular disease (CVD) is proven, but why some adults with obesity develop CVD while others remain disease-free is poorly understood. Here, we investigated whether mitochondrial DNA (mtDNA) methylation in platelets is altered prior to CVD development in a population of adults with overweight and obesity.We devised a nested case-control study of 200 adults with overweight or obesity who were CVD-free at...