Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis

Volume: 5, Issue: 1
Published: Feb 27, 2020
Abstract
We conducted DNA methylation association analyses using Illumina 450K data from whole blood for an Australian amyotrophic lateral sclerosis (ALS) case–control cohort (782 cases and 613 controls). Analyses used mixed linear models as implemented in the OSCA software. We found a significantly higher proportion of neutrophils in cases compared to controls which replicated in an independent cohort from the Netherlands (1159 cases and 637 controls)....
Paper Details
Title
Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis
Published Date
Feb 27, 2020
Volume
5
Issue
1
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