Citrullination regulates wound responses and tissue regeneration in zebrafish
Abstract
Calcium is an important early signal in wound healing, yet how these early signals promote regeneration remains unclear. Peptidylarginine deiminases (PADs), a family of calcium-dependent enzymes, catalyze citrullination, a post-translational modification that alters protein function and has been implicated in autoimmune diseases. We generated a mutation in the single zebrafish ancestral pad gene, padi2, that results in a loss of detectable...
Paper Details
Title
Citrullination regulates wound responses and tissue regeneration in zebrafish
Published Date
Mar 4, 2020
Journal
Volume
219
Issue
4
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