Abstract P193: Lipidomics of APOE Genotype Among Older Black Men Revealed ε2 Carriers Were More Different and ε4 Carriers Were Less Different When Compared to ε3 Homozygous

Introduction: The ability of apolipoprotein E (APOE) to regulate lipid metabolism in the brain and periphery is impacted by APOE genotype. The ε4 and ε2 variants are associated with higher and lower risks of Alzheimer’s disease, respectively, than ε3 homozygous. The ε4 variant is also associated with a higher cardiovascular disease risk. Differences in lipoprotein affinity by APOE genotype can cause altered profiles of plasma lipids and...