Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution
Abstract
Whole-genome doubling (WGD) is a prevalent event in cancer, involving a doubling of the entire chromosome complement. However, despite its prevalence and prognostic relevance, the evolutionary selection pressures for WGD in cancer have not been investigated. Here, we combine evolutionary simulations with an analysis of cancer sequencing data to explore WGD during cancer evolution. Simulations suggest that WGD can be selected to mitigate the...
Paper Details
Title
Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution
Published Date
Mar 1, 2020
Journal
Volume
52
Issue
3
Pages
283 - 293
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