Testing association of rare genetic variants with resistance to three common antiseizure medications

Stefan Wolking; Claudia Moreau; Anne T. Nies; Elke Schaeffeler; Mark McCormack; Pauls Auce; Andreja Avbersek; Felicitas Becker; Martin Krenn; Rikke S. Møller; Simon L. Girard; Holger Lerche

doi:https://doi.org/10.1111/epi.16467

doi.org/10.1111/epi.16467

Testing association of rare genetic variants with resistance to three common antiseizure medications

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,

..., Holger Lerche

21

Epilepsia5.60

Volume: 61, Issue: 4, Pages: 657 - 666

Published: Mar 6, 2020

Abstract

Objective Drug resistance is a major concern in the treatment of individuals with epilepsy. No genetic markers for resistance to individual antiseizure medication (ASM) have yet been identified. We aimed to identify the role of rare genetic variants in drug resistance for three common ASMs: levetiracetam (LEV), lamotrigine (LTG), and valproic acid (VPA). Methods A cohort of 1622 individuals of European descent with epilepsy was deeply phenotyped...

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Paper Details

Title

Testing association of rare genetic variants with resistance to three common antiseizure medications

DOI

doi.org/10.1111/epi.16467

Published Date

Mar 6, 2020

Journal

Epilepsia

Volume

61

Issue

4

Pages

657 - 666

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