Abstract P271: Dna Methylation Measures of Aging in Midlife are Associated With Frailty Components in African American and European American Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study

Introduction: Several putative biomarkers of accelerated biological aging have been developed from patterns of DNA methylation in blood and other tissues (DNAm-Age scores). Some of these DNAm-Age scores have been found to be associated with age-related outcomes such as CVD and all-cause mortality, but their associations with frailty are unclear. We hypothesized that higher DNAm-Age scores measured in midlife are associated with higher odds of...