Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis
Abstract
Although it is well-established that reductions in the ratio of insulin to glucagon in the portal vein have a major role in the dysregulation of hepatic glucose metabolism in type-2 diabetes1–3, the mechanisms by which glucagon affects hepatic glucose production and mitochondrial oxidation are poorly understood. Here we show that glucagon stimulates hepatic gluconeogenesis by increasing the activity of hepatic adipose triglyceride lipase,...
Paper Details
Title
Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis
Published Date
Mar 4, 2020
Journal
Volume
579
Issue
7798
Pages
279 - 283
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Notes
History