IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF GERMLINE GENETIC VARIANTS PREDISPOSING TO DIFFERENTIATED THYROID CANCER RISK

Differentiated thyroid cancer (DTC) is the most common endocrine tumor, showing a high incidence in Italy. A significant higher risk of this cancer is described in first-degree relatives of DTC patients compared to the general population suggesting that germline genetic variants may contribute to its development. Previous genome-wide association studies (GWASs) on DTC have identified robust associations with single nucleotide polymorphisms...