Original paper
MagnEdit—interacting factors that recruit DNA-editing enzymes to single base targets
Abstract
Although CRISPR/Cas9 technology has created a renaissance in genome engineering, particularly for gene knockout generation, methods to introduce precise single base changes are also highly desirable. The covalent fusion of a DNA-editing enzyme such as APOBEC to a Cas9 nickase complex has heightened hopes for such precision genome engineering. However, current cytosine base editors are prone to undesirable off-target mutations, including, most...
Paper Details
Title
MagnEdit—interacting factors that recruit DNA-editing enzymes to single base targets
Published Date
Feb 24, 2020
Journal
Volume
3
Issue
4
Pages
e201900606 - e201900606
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Notes
History