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Unfolding the electrospinning potential of biopolymers for preparation of nanofibers

Published on Jun 1, 2020in Journal of Drug Delivery Science and Technology2.606
· DOI :10.1016/J.JDDST.2020.101604
Ritu Jain1
Estimated H-index: 1
,
Saritha Shetty1
Estimated H-index: 1
+ 0 AuthorsKhushwant S. Yadav10
Estimated H-index: 10
Abstract
Abstract Nanofibers have unique potentials in tissue engineering, medical devices, drug delivery, diagnostics etc. due to their exceptional properties like high porosity, large surface area to volume ratio, functionality flexibility, good mechanical strength etc. Nanofibers prepared by electrospinning has grabbed the attention of many recently due to the flexibility and tailoring properties of biopolymers. Various manufacturing variables that affect the morphology of nanofibers and other processing parameters have been discussed in this review article. Besides these parameters, different techniques used for incorporating the drug into nanofibers have also been emphasized. The focused material for electrospinning the nanofibers are the novel polymers and the co-polymers that enrich the electrospun process with their unique physicochemical properties. The recent surge towards biopolymers, such as alginates, chitosan, hyaluronic acid, kefiran, pullulan has attracted enough attention in the preparation of nanofibers due to their properties like modifiability, biodegradability, biocompatibility and biological activities. The other novel biopolymers that have been discussed include tree gum, wheat protein, soy protein, zein. This article provides an insight towards these novel biopolymers along with their application in drug delivery.
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  • Citations (1)
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References120
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#2Wen-Hao DongH-Index: 2
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#1Zahra Moradi (Urmia University)H-Index: 1
#2Nastaran Kalanpour (Urmia University)
Abstract Considering harmful effects of the environmental pollution and increased concerns about the synthetic polymers, kefiran has been introduced as a biodegradable polymer due to its nontoxicity. This edible biopolymer and its structural derivations play specific roles in a large number of applications including scaffolds, the reserve materials, and the encapsulation for drug delivery, thanks to its amazing properties such as the protective features, the bifidogenic effects and the antimicro...
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#1Xu Yan (Qingdao University)H-Index: 13
#2Miao Yu (Qingdao University)H-Index: 15
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Electrospinning and electrospun fibrous assemblies have attracted interest in a variety of biomedical fields including woundcare, tissue engineering and drug delivery, due to the large surface-area-to-volume ratio and high porosity of nanofibrous webs. Normally, wound dressings are manufactured well before the point of care, and then packaged and distributed for use at a later stage. More recently, in situ electrospinning of fibers directly onto wound sites has been proposed as a route to person...
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#1Ze-yu Qin (NEAU: Northeast Agricultural University)H-Index: 1
#2Xi-Wen Jia (NEAU: Northeast Agricultural University)H-Index: 1
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Abstract In this study, Chitosan/pullulan composite nanofiber fast dissolving oral films (FDOFs) were prepared via electrospinning technology. The ratio of chitosan/pullulan (C/P) had an influence on solution property and nanofiber morphology, with the increase of chitosan, viscosity and conductivity of solutions increased, the morphology obtained by scanning electron microscopy indicated that the diameter of nanofibers decreased initially then increased. The Fourier transform infrared spectra i...
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Abstract In healthy individuals, wound healing is a highly efficient process. However, interruptions of normal healing give rise to chronic wounds, characterized by inflammation with impaired angiogenesis and re-epithelialization. The aim of this work was the design and the development of electrospun nanofibrous scaffolds based on sodium alginate (SA) and pullulan (PUL) and loaded with human platelet lysate (PL) intended for skin reparation, to take the advantage of nanofibrous scaffolds (with i...
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#1Yadong Tang (Wuyi University)H-Index: 1
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Abstract Honey is an ancient natural wound-healing agent and has been reintroduced to modern clinical wound care as it has various bioactivities. In this study, honey was incorporated into an alginate/PVA-based electrospun nanofibrous membrane to develop an efficient wound dressing material. The morphology and chemical composition of the nanofibrous membrane were observed by scanning electron microscopy and characterized via Fourier transform infrared spectroscopy, respectively, demonstrating th...
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Abstract Resveratrol loaded chitosan:gellan (CS:Gel) nanofibers (NFs) were prepared for the first time using electrospinning technique. The NFs were prepared with CS (9% w/v) in trifloroacetic acid and Gel (2.5% w/v) at a concentration ratio of 95:5% w/v. Based on the scanning electron microscopy (SEM) images, the diameters of CS-Gel fibers at a ratio of 95:5 and 90:10% w/v were 166 ± 37 and 291 ± 41 nm, respectively. Resveratrol (0.05% w/v) was loaded in NFs of CS-Gel at a ratio of 95:5. Encaps...
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#1Emine Merve Çanga (Hacettepe University)
#2Fahriye Ceyda Dudak (Hacettepe University)H-Index: 10
Abstract Fruits of Viburnum opulus L. (also called European cranberry) are well known for their high antioxidant activity. In this work, novel encapsulation matrices were fabricated by electrospinning of cellulose acetate (CA) and gum Arabic (GA) blends in different compositions and their performance for encapsulation of Viburnum opulus L. fruit extract was evaluated. Scanning electron microscopy (SEM) results showed that CA-GA hybrid fibers were bead-free and smooth, exhibiting diameters rangin...
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#1Sepideh Dadashi (IAU: Islamic Azad University)
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Abstract Kefiran is a microbial biopolymer which is able to form nanofibers with specific characteristic features. The present study demonstrated the successful fabrication of drug loaded kefiran nanofibrous mats by electrospinnig method. Nanofibrous mats were characterized using Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR). SEM images revealed bead free nanofibers with the average diameter of 300 nm. In addition, 1200 μg/mL concentration of doxycycline w...
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#1Pranabesh Sasmal (Indian Institute of Engineering Science and Technology, Shibpur)H-Index: 1
#2Pallab Datta (Indian Institute of Engineering Science and Technology, Shibpur)H-Index: 12
Abstract The work reports fabrication of hemostatic patches containing an antifibrinolytic agent with an antibacterial, hemostat polymer. Membranes were fabricated by electrospinning technique. Hemostatic membranes were characterized for swelling, morphology, mechanical, thrombosis and drug release properties. Delivery systems containing 40 mg/ml of tranexamic acid (TXA) could be successfully fabricated. Clotting time (CT) of nanofiber membranes fabricated with 1:1 poly (vinyl alcohol) (PVA): ch...
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Cited By1
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#1Hadis Rostamabadi (Gorgan University)H-Index: 3
#2Elham Assadpour (Gorgan University)H-Index: 16
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Abstract Background Electrospinning is an approach relying on the processing of (bio)polymeric solutions/melts over high electrical voltages to generate fibrous micro/nano-structures of proper nature; with post optimization of process variables. Scope and approach The present study will offer an overview on recent advancements in electrospinning-based fabrication of nanocarriers for nanoencapsulation of different bioactive components. The main principles, instrumental set-up, pros and cons of el...
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