Mechanisms of Macrophage Polarization in Insulin Signaling and Sensitivity

Type-2 diabetes (T2D) is a disease of two aetiologies: metabolic and inflammatory. At the cross-section of these aetiologies lays the phenomenon of metabolic inflammation. Whilst metabolic inflammation is characterised as systemic, a common starting point is the tissue-resident macro-phage, who’s successful physiological or aberrant pathological adaptation to its microenvironment determines disease course and severity. This review will highlight...