Modulation of tau protein aggregation using ‘Trojan’ sequences

Volume: 1864, Issue: 7, Pages: 129569 - 129569
Published: Jul 1, 2020
Abstract
The abnormal assembly of tau into neurofibrillary tangles has been associated with over 30 debilitating disorders known as tauopathies. Tauopathies affect millions of people worldwide, yet no clinically approved solution for tau aggregation is currently available.We employed a structure-based design approach to make a series of short peptide-based perturbants (Trojans), that can interact with the core hydrophobic fragment of tau protein. Through...
Paper Details
Title
Modulation of tau protein aggregation using ‘Trojan’ sequences
Published Date
Jul 1, 2020
Volume
1864
Issue
7
Pages
129569 - 129569
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