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A full factorial experimental design to study the effect of flavoring agents on the mechanical properties of curcumin chewing gum tablets with high solids content.

Published on Mar 5, 2020in Drug Development and Industrial Pharmacy2.367
· DOI :10.1080/03639045.2020.1734019
Turki Al Hagbani2
Estimated H-index: 2
(ULM: University of Louisiana at Monroe),
Mohammad M. Kamal3
Estimated H-index: 3
(ULM: University of Louisiana at Monroe),
Sami Nazzal22
Estimated H-index: 22
(TTUHSC: Texas Tech University Health Sciences Center)
Abstract
AbstractObjective: Developing chewing gum tablets (CGTs) with high drug loads is a challenge due to the loss of mastication properties. We postulated that poor mastication properties of such gums c...
  • References (17)
  • Citations (0)
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References17
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#1Turki Al Hagbani (ULM: University of Louisiana at Monroe)H-Index: 2
Last. Sami Nazzal (ULM: University of Louisiana at Monroe)H-Index: 22
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#1Turki Al Hagbani (ULM: University of Louisiana at Monroe)H-Index: 2
#2Sami Nazzal (ULM: University of Louisiana at Monroe)H-Index: 22
Medicated chewing gum tablets (CGTs) represent a unique platform for drug delivery. Loading directly compressible gums with high concentrations of powdered medication, however, results in compacts with hybrid properties between a chewable gum and a brittle tablet. The aim of the present study was to develop textural tests that can identify the point at which CGTs begin to behave like a solid tablet upon drug incorporation. Curcumin (CUR) CGTs made with Health in gum® were prepared with increasin...
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#2P ThreepopnatkulH-Index: 1
Fish skin gelatin films incorporated with peppermint and citronella essential oils at difference concentrations (10, 20 and 30% w/w) were prepared by solution casting. Addition of peppermint oil contributed to a significant decrease of tensile strength and Young's modulus, while the percent elongation at break showed an obvious increase except at 30% w/w. On the other hand, addition of citronella oils promoted a great increase of tensile strength and young's modulus, but an intense decrease of t...
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New formulations and technologies have been developed through oral drug delivery systems’ researches. Such researches display significance of oral route amongst patients. We’ve reviewed all the features associated with medicated chewing gum as a modern drug delivery by introducing the history, advantages and disadvantages, methods of manufacturing, composition differences, evaluation tests and examples of varieties of medicated chewing gums. Acceptance of medicated chewing gum has been augmented...
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Abstract Properties of protein-based film from fish skin gelatin incorporated with different citrus essential oils, including bergamot, kaffir lime, lemon and lime (50% based on protein) in the presence of 20% and 30% glycerol were investigated. Films containing 20% glycerol had higher tensile strength (TS) but lower elongation at break (EAB), compared with those prepared with 30% glycerol, regardless of essential oils incorporated ( p p p E * (total colour difference) , where the highest value ...
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Beside the efficient effect on masking cetirizine bitter taste, the cyclodextrins (CDs) as well could have influence on the release from the formulation. In vitro release profiles of cetirizine from compressed chewing gums containing α-, β- and γ-CD were investigated using a three cell chewing apparatus. Different cetirizine/CD formulations were produced and analysed with respect to type of CD (α-, β- and γ-CD), the molar ratio between cetirizine and CD and the formulation of cetirizine (complex...
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The purpose of this study was to extend QbD principles to liposomal drug products containing a hydrophilic active pharmaceutical ingredient (API) to demonstrate both the feasibility and the advantages of applying QbD concepts to liposome based complex parenteral controlled release systems. The anti-viral drug Tenofovir was selected as a model compound. Desired properties for two of the key liposome drug product qualities, namely the particle size and drug encapsulation efficiency, were defined a...
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#2Mysore S. VeenaH-Index: 14
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Purpose: To determine whether curcumin would inhibit IKK beta kinase activity and suppress expression of proinflammatory cytokines in head and neck cancer (HNSCC) patients. Experimental Design: Saliva was collected before and after subjects chewed curcumin tablets. Protein was extracted and IKK beta kinase activity measured. IL-6 and IL-8 levels in salivary supernatants were measured using ELISA. IL-6, IL-8 and other interleukins were also measured independently with ELISA to confirm the inhibit...
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#2Gar Yee Koh (Louisiana State University Agricultural Center)H-Index: 5
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ABSTRACT: Curcumin (CUR) is an active food compound, but its insolubility and instability in water contributes to low bioavailability. In this study, the solubility of CUR was enhanced by utilizing the solubilizing properties of rubusoside (RUB). The solubility of CUR in water increased linearly from 61 μg/mL to 2.318 mg/mL in the presence of RUB ranging from 1% to 10% (w/v). Dynamic light scattering and transmission electron microscopy studies found that CUR and RUB formed CUR–RUB nanoparticle ...
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Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant, commonly known as turmeric. Curcumin has been used extensively in Ayurvedic medicine for centuries, as it is nontoxic and has a variety of therapeutic properties including anti-oxidant, analgesic, anti-inflammatory and antiseptic activity. More recently curcumin has been found to possess anti-cancer activities via its effect on a variety of biological pathways involved in mutagenesis, oncogene expression, cell cyc...
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