Leukotriene D4 antagonizes CysLT2 receptor signaling and LTC4-driven immunopathology in vivo

The three cysteinyl leukotrienes (cysLTs), (LT)C4, LTD4, and LTE4, have different biological half-lives, cellular targets, and receptor specificities. LTC4, but not LTD4, activates platelets and elicits their CysLT2R-dependent release of IL-33 ex vivo. LTC4 strongly potentiates allergen-induced pulmonary eosinophilia through a CysLT2R-mediated, platelet- and interleukin-33 dependent pathway in vivo that is not recapitulated by LTD4. We now...