Curcumin-incorporated Thiolated Chitosan/alginate Nanocarriers: Physicochemical Properties and Release Mechanism

This study was aimed to develop thiolated chitosan/alginate nanoparticles for curcumin delivery. The nanoparticles were prepared from thiolated chitosan and sodium alginate using an ionic gelation technique. The concentrations of thiolated chitosan and alginate used to form the nanoparticles were optimal at 0.05 and 0.025 % w/v, respectively. Curcumin was incorporated into the nanoparticles by entrapment during nanoparticle preparation. The...