Multiple Dose Pharmacokinetic Models Predict Bioavailability of Toxins in Vertebrate Herbivores
Abstract
In this paper, compartmental pharmacokinetic models are built to predict the concentration of toxic phytochemical in the gastrointestinal tract and blood following oral intake by an individual vertebrate herbivore. The existing single and multiple dose pharmacokinetic models are extended by inclusion of impulsive differential equations which account for an excretion factor whereby unchanged toxins are excreted in the feces due to...
Paper Details
Title
Multiple Dose Pharmacokinetic Models Predict Bioavailability of Toxins in Vertebrate Herbivores
Published Date
Feb 1, 2020
Journal
Volume
46
Issue
2
Pages
198 - 205
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