LPS induces ALOX5 promoter activation and 5-lipoxygenase expression in human monocytic cells

Volume: 154, Pages: 102078 - 102078
Published: Mar 1, 2020
Abstract
5-lipoxygenase (5-LO), coded by the ALOX5 gene, is expressed in leukocytes and catalyzes the formation of leukotrienes, pro-inflammatory lipid mediators. Leukotrienes are central to immune responses, but are also involved in inflammatory disorders and 5-LO expression is associated with leukemia stem cell survival. It is therefore important to understand mechanisms that control 5-LO expression. This study investigated the control of 5-LO...
Paper Details
Title
LPS induces ALOX5 promoter activation and 5-lipoxygenase expression in human monocytic cells
Published Date
Mar 1, 2020
Volume
154
Pages
102078 - 102078
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