EGb761 ameliorates cell necroptosis by attenuating RIP1-mediated mitochondrial dysfunction and ROS production in both in vivo and in vitro models of Alzheimer’s disease

To investigate the neuroprotective effect of Gingko biloba extract 761 (EGb761) in Alzheimer’s disease (AD) models both in vivo and in vitro and the underlying molecular mechanism. Cultured BV2 microglial cells were treated with Aβ1-42 to establish an in vitro AD model. The in vivo rat AD model was established by injecting Aβ1-42. Cells were pre-treated with EGb761, and the proliferation and necroptosis were examined by MTT or flow cytometry...