Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling
Abstract
Genetically encoded photoswitches have enabled spatial and temporal control of cellular events to achieve tailored functions in living cells, but their applications to probe the structure-function relations of signaling proteins are still underexplored. We illustrate herein the incorporation of various blue light-responsive photoreceptors into modular domains of the stromal interaction molecule 1 (STIM1) to manipulate protein activity and...
Paper Details
Title
Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling
Published Date
Feb 25, 2020
Journal
Volume
11
Issue
1
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