α-Tubulin detyrosination impairs mitotic error correction by suppressing MCAK centromeric activity

Volume: 219, Issue: 4
Published: Feb 28, 2020
Abstract
Incorrect kinetochore–microtubule attachments during mitosis can lead to chromosomal instability, a hallmark of human cancers. Mitotic error correction relies on the kinesin-13 MCAK, a microtubule depolymerase whose activity in vitro is suppressed by α-tubulin detyrosination—a posttranslational modification enriched on long-lived microtubules. However, whether and how MCAK activity required for mitotic error correction is regulated by α-tubulin...
Paper Details
Title
α-Tubulin detyrosination impairs mitotic error correction by suppressing MCAK centromeric activity
Published Date
Feb 28, 2020
Volume
219
Issue
4
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