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Impact of a Nutritional Supplement During Gestation and Early Childhood on Child Salivary Cortisol, Hair Cortisol, and Telomere Length at 4-6 Years of Age: A Follow-Up of a Randomized Controlled Trial

Published on Feb 24, 2020in Stress2.168
· DOI :10.1080/10253890.2020.1728528
Brietta M Oaks7
Estimated H-index: 7
(URI: University of Rhode Island),
Seth Adu-Afarwuah12
Estimated H-index: 12
(University of Ghana)
+ 9 AuthorsHarriet Okronipa8
Estimated H-index: 8
(UC Davis: University of California, Davis)
Abstract
Dysregulation of the stress response can occur early in life and may be affected by nutrition. Our objective was to evaluate the long-term effect of nutritional supplementation during gestation and early childhood on child cortisol and buccal telomere length (a marker of cellular aging) at 4-6 years of age. We conducted a follow-up study of children born to women who participated in a nutritional supplementation trial in Ghana. In one group, a lipid-based nutrient supplement (LNS) was provided to women during gestation and the first 6 months postpartum and to their infants from age 6 to 18 months. The control groups received either iron and folic acid (IFA) during gestation or multiple micronutrients during gestation and the first 6 months postpartum, with no infant supplementation. At age 4-6 years, we measured hair cortisol, buccal telomere length, and salivary cortisol before and after a stressor. Salivary cortisol was available for 364 children across all three trial arms and hair cortisol and telomere length were available for a subset of children (n = 275 and 278, respectively) from the LNS and IFA groups. Telomere length, salivary cortisol, and hair cortisol did not differ by supplementation group. Overall, these findings suggest that nutritional supplementation given during gestation and early childhood does not have an effect on child stress response or chronic stress in children at 4-6 years. Trial registration: ClinicalTrials.gov Identifier NCT00970866.Lay SummaryThis study addressed a research gap about whether improved nutrition during pregnancy and early childhood impacts telomere length and cortisol in preschool children. There was no difference in child telomere length or cortisol between two trial arms of a nutritional supplementation trial that began during pregnancy. The research outcomes indicate lipid-based nutrient supplements, a relatively new form of supplementation, do not have an effect on markers of stress or cellular aging measured in later childhood.
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References37
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#1Sika M Kumordzie (UC Davis: University of California, Davis)H-Index: 4
#2Seth Adu-Afarwuah (University of Ghana)H-Index: 12
Last. Kathryn G. Dewey (UC Davis: University of California, Davis)H-Index: 12
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Author(s): Kumordzie, Sika M; Adu-Afarwuah, Seth; Arimond, Mary; Young, Rebecca R; Adom, Theodosia; Boatin, Rose; Ocansey, Maku E; Okronipa, Harriet; Prado, Elizabeth L; Oaks, Brietta M; Dewey, Kathryn G | Abstract: BACKGROUND:Few studies have evaluated the long-term effects of nutritional supplementation during the first 1000 d of life. We previously reported that maternal and child lipid-based nutrient supplements (LNS) increased child length by 18 mo. OBJECTIVE:The aim of this study was to ex...
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#2Rebecca T Young (UC Davis: University of California, Davis)H-Index: 4
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Gestation is a time of profound vulnerability, as insults during pregnancy increase the lifelong risk of morbidity for the offspring. Increasingly, maternal diet is recognized as a key factor influencing the developing fetus. Poor-quality maternal diets, whether they provide an excess or an insufficiency of nutrients, lead to overt gestational growth disturbances in the offspring, and elevated risk for a common cluster of metabolic and mental disorders. Metabolic disturbances, particularly a sub...
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Telomeres ensure genome integrity during replication. Loss of telomeric function leads to cell immortalization and accumulation of genetic alterations. The association of telomere length (TL) with breast cancer prognosis is examined through a systematic review. Electronic databases (MEDLINE, EMBASE, CENTRAL), from inception to December 2015, and relevant reviews were searched. Studies that evaluated TL (blood and/or tumor) in association with breast cancer survival or prognostic factor were incl...
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