Inhibition of fatty acid amide hydrolase in the CNS prevents and reverses morphine tolerance in male and female mice

Background and Purpose Fatty acid amide hydrolase (FAAH) is an intracellular serine amidase that terminates the signalling of various lipid messengers involved in pain regulation, including anandamide and palmitoylethanolamide. Here, we investigated the effects of pharmacological or genetic FAAH removal on tolerance to the anti‐nociceptive effects of morphine. Experimental Approach We induced tolerance in male and female mice by administering...